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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomesequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy.The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract: Accompanied by a powerful computational data analysis method, new genome-wide screening approaches wereThis review focused on advanced genome-wide screening approaches in fusion gene identification, such

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine doi: 10.1007/s11684-023-1008-8

Abstract: architecture of chromatin influences various genomic regulators and subsequent gene expression in human cancerHowever, knowledge of the topological rearrangement of genomic hierarchical layers in cancer is largelyFurthermore, the chromatin short loops and cancer unique loops associated with chromatin remodeling andCancer-specific enhancer–promoter loops, which contain multiple transcription factor binding motifs,Collectively, our data offer the landscape of hierarchical layers of cancer genome and functional alterations

Keywords： 3D genome     cancer     TADs     loop     gene regulation    

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Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 444-450 doi: 10.1007/s11684-012-0225-3

Abstract:

Genome-wide association studies (GWAS) have achieved great success in identifying genetic variantsrelated to complex human diseases such as cancer and have provided valuable insights into their genetic

Keywords： genome-wide association studies (GWAS)     genetic variant     cancer     limitation     challenge    

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortnucleases and the state of the art and new insights into practical applications and social acceptance of genomeIt is concluded that the production of gene-edited ruminants is feasible and through improvements in genome

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: Inspired by the Material Genome Initiative as issued in 2011 by the United States of America, a morespecific and focused project initiative was proposed in this paper—the liquid metal material genome aimedtheoretical strategies and experimental methods in the research and development of liquid metal material genomeThe liquid metal material genome proposal as initiated in this paper will accelerate the process of finding

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityfor microbial genome.In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing in

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: The advent of genome-wide association studies (GWAS) has hastened the progress of polygenic obesity research

Keywords： obesity     genetics     genome-wide association studies     body mass index     fat mass- and obesity-associated gene    

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Information Science Should Take a Lead in Future Biomedical Research Perspective

Kenta Nakai

Engineering 2019, Volume 5, Issue 6,   Pages 1155-1158 doi: 10.1016/j.eng.2019.07.023

Abstract: Similar approaches could contribute to solving problems in genome sequence interpretation, such as identifyingcancer-driving mutations in the genome of patients.

Keywords： Data science     Artificial intelligence     Next-generation sequencing     DNA     Cancer genome     Single-cell transcriptomics    

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A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract:

The recent development of genome editing technologies has given researchers unprecedented power toThis mini-review briefly summarizes the development of major genome editing tools, focusing on the application

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

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Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 121-122 doi: 10.15302/J-FASE-2019317

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract: Genome editing technology with its ability to directly introduce beneficial sequence variants offersThis review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Title Author Date Type Operation

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Journal Article

Genome-wide association studies: inherent limitations and future challenges

Yan Du, Jiaxin Xie, Wenjun Chang, Yifang Han, Guangwen Cao

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Information Science Should Take a Lead in Future Biomedical Research

Kenta Nakai

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Journal Article

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article